The present study used biotelemetry to provide a fine-grained analysis of the effects of GHB oil body temperature and locomotor activity in freely moving rats, and investigated interactions between GHB and 3,4-methylenedioxymethamphetamine (MDMA), methamphetamine (METH) and various antagonist drugs. GHB (1000 mg/kg) caused profound sedation for more than 2 h and a complex triphasic effect on body temperature: an initial hypothermia (5-40 min), followed by hyperthermia (40-140 min), followed again by hypothermia (140-360 min). A

lower GHB close (500 mg/kg) also Caused sedation but Only a hypothermic effect that lasted up to 6 h. The dopamine D(1) receptor antagonist SCH 23390 (1 mg/kg), the opioid antagonist naltrexone (1 mg/kg), the benzodiazepine antagonist flumazenil (10 mg/kg), and the 5-HT(2A/2C) receptor antagonist ritanserin (1 mg/kg) Napabucasin ic50 did not prevent the overall

sedative or body temperature effects of GHB (1000 mg/kg). However the GABA(B) antagonist SCH 50911 (50 mg/kg) prevented the hyperthermia induced by GHB (1000 mg/kg). Repeated daily administration of GHB (1000 mg/kg) produced tolerance to the sedative and hyperthermic effects of the drug and cross-tolerance to the sedative effects of the GABA(B) receptor agonist baclofen (10 mg/kg). A high ambient temperature of 28 degrees C prevented the hypothermia obtained with GHB (500 mg/kg) at 20 degrees C, while GHB (500 mg/kg) reduced the hyperthermia and hyperactivity produced by co-administered doses of MDMA (5 mg/kg) or METH (1 mg/kg) at 28 degrees C. These Vorinostat in vivo results further confirm a role for GABA(B) receptors in the hypothermic and sedative effects of

GHB and show an interaction CX-6258 molecular weight between GHB and MDMA, and GHB and METH, that may be relevant to the experience of recreational users Who mix these drugs. (C) 2009 Elsevier Ireland Ltd. All rights reserved.”
“We have characterized the melt rheological behavior and the solid tensile properties of sawdust/polyethylene composites prepared in an internal mixer. Various concentrations (from 0 to 60 wt %) and three particle sizes have been tested, in presence of a coupling agent (maleic anhydride grafted polyethylene). In the molten state, for each particle size, a mastercurve of the complex viscosity as function of frequency can be plotted, using a shift factor depending oil weight fraction. We show that the shift factors can be described by a Krieger-Dougherty law, leading to a “”universal”" viscosity law of the Carreau-Yasuda type. In the solid state, the presence of sawdust increases Young modulus in uniaxial elongation, mainly for small size particles, but reduces dramatically deformation at break and tensile strength. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 112: 2559-2566, 2009″
“Background: Urticaria is a common and frequently debilitating disease.