Results:

One hundred eighteen women (mean age, 56.2 years), representing 4.1% of the screening cohort, had an indeterminate adnexal mass (108 unilateral, 10 bilateral; mean size, 4.1 cm) at prospective CT interpretation. A total of 80 women underwent some combination of further imaging evaluation (n = 76) (transvaginal ultrasonography [n = 71], pelvic magnetic resonance imaging [n = 7], contrast material-enhanced CT [n = 7]) and/or surgery (n = 26). Mean serum CA-125 level in 33 women was 12.8 U/mL; levels were normal (, 35 U/mL) in 32 (97%) cases (range, 3-26 U/mL) and mildly elevated (41 U/mL) in one case. Final pathologic findings of surgically excised lesions were cystadenoma or cystadenofibroma selleck chemicals (n = 14; 11 serous, three mucinous); nonneoplastic cysts (n = 5; two endometriomas); mature teratoma (n = 3); hydrosalpinx (n = 2); fibroma (n = 1); and benign Brenner tumor (n = 1). Three additional teratomas were diagnosed at index CT only. No ovarian cancers were prospectively identified, although four

cases of ovarian cancer developed subsequent to a negative Autophagy Compound Library in vitro adnexal finding at CT examination during a 15-44-month interval among the remaining 2751 women.

Conclusion: Incidental indeterminate adnexal lesions were relatively common at unenhanced CT (4.1%), but subsequent work-up revealed no ovarian cancers. Furthermore, a normal finding at CT was not protective against short-term development of ovarian cancer. More sophisticated risk factor assessment is needed to identify women at higher risk.

(C) RSNA, 2010″
“The effects induced during the covering/embedding of metal nanoparticles (NPs) produced by pulsed laser deposition (PLD) and their impact on the structural and optical properties have been studied by producing pairs of samples containing Au NPs that are either uncovered (i.e., at the surface) or covered (i.e., embedded in an amorphous a-Al2O3 host). The main result is that covering species can sputter up to 100% of the Au atoms, the smaller the NPs the higher the sputtered fraction. This fraction has been simulated using standard models for ion bombardment and taking into account the kinetic energy distribution of arriving species and the cohesive energy dependence on NPs dimensions. Although all models well predict the order of magnitude learn more of the sputtering yield, the calculated values are generally smaller than the experimental ones and do not account for the experimental dependence on NPs dimensions. This disagreement is discussed in terms of the limitations of standard models that do not take into account the lower adhesion of small NPs to the substrate, the high flux of species involved in PLD and, possibly to lesser extent, the use of some bulk material parameters. The metal sputtering during the coverage regulates the NPs morphology, through a reduction of dimensions and dimension dispersion.