71% respectively, the intervention group was significantly lower than the control group Conclusion: Through effective nursing intervention to reduce the incidence of postoperative adverse reactions, improves patient’s quality of life. Key Word(s): 1. Liver biopsy; 2. Adverse reactions; 3. Nursing intervention; Presenting Author: ODD HELGE GILJA Additional

Authors: FREDRIK SAEVIK, KIM NYLUND, TRYGVE HAUSKEN Corresponding Author: ODD HELGE GILJA Affiliations: Haukeland Palbociclib purchase University Hospital Objective: Crohn’s disease is characterized by periods of remission and relapse. To improve patient management objective measurements of the degree of local inflammation in the gastrointestinal wall should be made. Increased microvessel density and perfusion are typical features of acute inflammation. Indirect measurements of these parameters can be measured using contrast-enhanced ultrasound (CEUS). The aim of this study was to investigate whether CEUS can provide prognostic information about patients treated medically for an acute exacerbation of Crohn’s disease. Methods: 13 patients with Crohn’s disease were prospectively recruited in a pilot study at Haukeland University Hospital. All patients received medical treatment for an acute exacerbation with systemic steroids, adalimumab or infliximab. Patients who had to change treatment regime during

the follow-up were categorized as having lack of treatment effect. The Resveratrol patients were examined at time AZD6244 0, 1, 3 and 12 months after initiation of the treatment with clinical scoring, blood tests and CEUS. Ultrasound was performed with a Logiq E9 ultrasound scanner (GE Healthcare, Milwaukee, USA) and contrast agents (Sonovue, Bracco, Milan Italy). The perfusion analysis was performed with commercially available software (Vuebox, Bracco Suisse SA, Geneva Switzerland). The program analyzes the contrast intensity in a selected

area, fits the data to a standardized curve and derives variables such as peak contrast intensity, area under the curve and slope of the curve. Results: In six of the 13 patients, the treatment regime was changed during the study period. There were no significant differences in perfusion between the two groups at the start of the treatment or examinations after 3 and 12 months. There was, however, a significant difference between the two groups for peak contrast intensity (p < 0,022), area under the curve (p < 0,05), during the wash in phase (p < 0,014), wash out phase (p < 0,07) and slope (wash in rate: p < 0,035, wash out rate: p < 0,014, respectively) at the examination one month after the initiation of the treatment. Conclusion: CEUS enables high-resolution perfusion analysis of the intestinal wall. One month after starting treatment in patients with Crohn’s disease prognostic information regarding treatment response can be obtained. Key Word(s): 1. Ultrasound; 2. CEUS; 3. Crohn’s disease; 4.