Thyroid autoantibodies and Tg were preoperatively estimated. Patients were classified according to the preoperative and histologically established diagnoses, and the median values of the biochemical markers were compared between the groups. Results. ITC was detected in 33/228 patients and almost exclusively in the presence of nontoxic thyroid disorders
(P = 0.014). There were no statistically significant differences in the median values of the biochemical markers between the benign and malignant groups. There was also no significant association between ITC and chronic lymphocytic thyroiditis. Conclusions. The co-existence of ITC with benign Sapanisertib supplier and especially nontoxic thyroid diseases is significant, and treatment of these disorders with TT when indicated can lead to the identification and definitive cure of microcarcinomas. Further studies are required to establish precise markers with prognostic validity for TC diagnosis.”
“Cell-based tissue engineering has emerged as a potential therapy for
intervertebral disc degeneration. However, propagating and maintaining high quantity and quality of the seed cells remains a challenge.
To investigate the feasibility of culturing human disc cells using a microcarrier bioreactor system.
Cell counts, growth patterns, cell cycles and cellular viability were examined during the course of cell cultivation and compared between the microcarrier bioreactor culture system and the conventional monolayer culture.
Cultures in the microcarrier bioreactor resulted in enhanced disc cell growth and satisfactory cell viability in comparison BIRB 796 molecular weight with the conventional monolayer culture. The cells in the microcarrier bioreactor cultivation exhibited higher S phase ratios, elevated Selleck ZVADFMK mitotic index and persistent exponential growth.
The microcarrier bioreactor culture system appears suitable for human disc cell propagation and may provide considerably more seeding cells for the tissue engineering process of intervertebral discs.”
“The relationship between macroscopic (elasticity, swelling), microstructural and molecular properties was investigated in soy protein hydrogels formed
by cross-linking to different degrees with a model Maillard type cross-linking agent (glutaraldehyde) in the absence or presence of 120 mM NaCl. Hydrogel macroscopic properties were not influenced by protein secondary structure. In contrast, rheological properties were strongly influenced by degree of cross-linking and microstructure. Cross-linking soy protein in the absence of salt led to the formation of a more porous network consisting of bigger flocs and/or bigger particles and to weaker gels. Gel swelling did not appear to depend on microstructural properties. The influence of cross-linking and salt on swelling would be connected to their respective impacts on elastic and ionic contributions to swelling. (C) 2008 Elsevier Ltd. All rights reserved.”
“Objective.