001. In subjects with Occult Hep B infection and chronic Hepatitis C there was more severe necro inflamation and fibrosis as compared to without occult Hep B

infection (p = 0005). Efficacy of antivral treatment 70% in occult Hep B positive Hep C patients Vs 85% in Occult B negativeHep C patients (p = 0.001). Conclusion: Conclusions: Occult Hep B infection is more common in Chronic Hep C patients than healthy subjects. Occult Hep B in chronic Hep C patients is assoiated with more advaced disease and less efficacy of antiviral treatment. It is a single center study, more studies are needed to confirm/refute our observation. Key Word(s): 1. occult hepatitis B; 2. chronic hepatitis C; Presenting Author: JING LAI Additional Authors: HAI-XIA SUN, KA ZHANG, WEI-QIANG R428 manufacturer GAN, YU-SHENG JIE Corresponding Author: JING LAI Objective: HBV related acute-on-chronic liver failure (ACLF)

is a clinical syndrome where acute hepatic insult manifesting as jaundice (serum total bilirubin (TBil) ≥ 5 mg/dL and coagulopathy (international normalized ratio (INR) ≥1.5), complicated within 4 weeks by ascites and/or encephalopathy in a patient with chronic HBV infection. But the correlation of hepatitis B surface antigen (HBsAg) level with INR in hepatitis B e antigen (HBeAg) negative ACLF has been scarcely investigated. The aim of this study was to retrospectively investigate the correlation Cell press of HBsAg levels with INR in patients receiving lamivudine. Methods: Fifty-seven HBeAg-negative ACLF patients were enrolled and treated with 100 mg of lamivudine Cilomilast in vivo daily. Serum levels of HBsAg and INR were detected at baseline,

before death (patients died within 12 weeks), week 12 (patients survived over 12 weeks). Dynamic of HBsAg and INR were analyzed. Results: Thirty-two patients were pretreatment HBsAg levels above 4000 COI, whose HBsAg and INR were 8096 ± 2535 COI, 2.39 ± 0.77 respectively at baseline but were 7509 ± 378 COI, 2.13 ± 0.77 in sequence after treatment. The other 25 patients were pretreatment HBsAg levels below to 4000 COI, whose HBsAg and INR were 3173 ± 2026 COI, 2.55 ± 0.73 respectively at baseline but were 2015 ± 1069 COI, 2.84 ± 0.78 in sequence after treatment. Significant differences were found in pre- and post-treatment HBsAg levels between two groups (all P > 0.05). No significant difference was found in pretreatment INR (t = 0.252, P = 0.802). However, post-treatment INR of patients with pretreatment HBsAg levels above 4000 COI was significantly lower than that of below to 4000 COI (t = −2.493, P = 0.019). Conclusion: In HBeAg-negative ACLF, the patients with higher HBsAg level may have better improvement of INR during lamivudine treatment. Key Word(s): 1. HBsAg level; 2. ACLF; 3. lamivudine; 4.